- Open Access
- Open Peer Review
Advocating "spine damage control" as a safe and effective treatment modality for unstable thoracolumbar fractures in polytrauma patients: a hypothesis
© Stahel et al; licensee BioMed Central Ltd. 2009
- Received: 17 February 2009
- Accepted: 11 May 2009
- Published: 11 May 2009
The "ideal" timing and modality of fracture fixation for unstable thoracolumbar spine fractures in multiply injured patients remains controversial. The concept of "damage control orthopedics" (DCO), which has evolved globally in the past decade, provides a safe guidance for temporary external fixation of long bone or pelvic fractures in multisystem trauma. In contrast, "damage control" concepts for unstable spine injuries have not been widely implemented, and the scarce literature in the field remains largely anecdotal. The current practice standards are reflected by two distinct positions, either (1) immediate "early total care" or (2) delayed spine fixation after recovery from associated injuries. Both concepts have inherent risks which may contribute to adverse outcome.
Presentation of hypothesis
We hypothesize that the concept of "spine damage control" – consisting of immediate posterior fracture reduction and instrumentation, followed by scheduled 360° completion fusion during a physiological "time-window of opportunity" – will be associated with less complications and improved outcomes of polytrauma patients with unstable thoracolumbar fractures, compared to conventional treatment strategies.
Testing of hypothesis
We propose a prospective multicenter trial on a large cohort of multiply injured patients with an associated unstable thoracolumbar fracture. Patients will be assigned to one of three distinct study arms: (1) Immediate definitive (anterior and/or posterior) fracture fixation within 24 hours of admission; (2) Delayed definitive (anterior and/or posterior) fracture fixation at > 3 days after admission; (3) "Spine damage control" procedure by posterior reduction and instrumentation within 24 hours of admission, followed by anterior 360° completion fusion at > 3 days after admission, if indicated. The primary and secondary endpoints include length of ventilator-free days, length of ICU and hospital stay, mortality, incidence of complications, neurological status and functional recovery.
Implications of hypothesis
A "spine damage control" protocol may save lives and improve outcomes in severely injured patients with associated spine injuries.
- Injured Patient
- Spine Fracture
- Fracture Fixation
- Femur Shaft Fracture
- Thoracolumbar Fracture
Polytrauma patients have a severely deranged immune response, characterized by an early excessive activation of innate immunity (hyperinflammation), followed by a delayed attenuation of adaptive immunity with decreased T-cell function (immunosuppression) and enhanced susceptibility to infection, sepsis, and multiple organ failure (MOF) [1, 2]. In addition, about a third of all multiply injured patients have severe disturbances of their clotting system on arrival to the emergency department, as determined by the presence of postinjury coagulopathy [3, 4]. This subset of patients has an increased incidence of MOF and death compared to severely injured patients who are not coagulopathic [3–6]. Historically, a "damage control" protocol was first advocated in terms of an abbreviated laparotomy for patients "in extremis" with massive bleeding from abdominal trauma, in order to allow restoration from the "lethal triad" of coagulopathy, hypothermia, and persistent metabolic acidosis [7, 8]. Aside from the traumatic "1st hit", the pathophysiological disturbance of the immune and clotting systems render multiply injured patients prone to sustaining aggravating "2nd hit" injuries related to inadequate timing and modality of surgical procedures [9, 10]. This notion has been well recognized for the management of long bone and pelvic fractures in polytrauma, leading to a worldwide implementation of the "damage control orthopedics" (DCO) strategy in the past decade . The concept of DCO entails a staged management of long bone and pelvic fractures by acute external fixation and delayed (scheduled) conversion to internal fixation during a physiological "time-window of opportunity" [1, 9, 10].
While the concepts and timing of fracture fixation for isolated spinal injuries – with or without neurological compromise – are well defined in the pertinent literature, the question about the "ideal" time-point of spine fracture fixation in severely injured patients remains an ongoing topic of debate. Few studies have assessed the impact of timing of spine fracture fixation on non-neurological outcome and complications. In a landmark article, Croce and colleagues performed a retrospective analysis of a prospective database on 291 consecutive patients with unstable spine fractures requiring surgical fixation . Patients were matched for injury severity and stratified by level of spine injury into two distinct cohorts, depending on the timing of fracture fixation: "early" fixation (within 3 days, n = 142) versus "late" fixation (> 3 days, n = 149). The authors found that the early fixation of thoracic spine fractures resulted in a lower incidence of pneumonia, fewer ventilator-dependent days, a shorter ICU stay, and reduced hospital charges . More recently, Cengiz et al. reported data from a randomized prospective pilot study on 27 patients who underwent surgical stabilization of an unstable fracture in the thoracolumbar region from T8 to L2 . Patients were allocated to two different groups based on the timing of surgery of definitive spine fracture fixation, either within 8 hours (n = 12) or more than 3 days (n = 15). The authors found that those patients who underwent spine fixation within 8 hours had a significantly decreased incidence of pulmonary complications, such as pneumonia, and shorter length of ICU and hospital stay, compared to the group with delayed spine fixation . Although this study has some significant shortcomings, such as the small patient population and the flawed randomization procedure based on the individual surgeon's operative schedule, these preliminary findings make a strong point that early spine fracture fixation is feasible and safe, and potentially beneficial for multiply injured patients . This notion was confirmed by a recent systematic review of the pertinent peer-reviewed literature in the field . In their review, Rutges et al. analyzed all published articles in Medline and Embase databases which provided a comparison between different time-points of surgical stabilization of thoracic or lumbar spine fractures . Ten papers encompassing 1,427 patients met the inclusion criteria. Based on their systematic review, the authors concluded that the early intervention for fracture stabilization in the thoracolumbar spine is safe, advantageous, and associated with a significantly decreased incidence of postoperative complications .
However, due to the lack of high level scientific evidence from prospective randomized trials, a consensus on the "ideal" timing of spine fracture fixation in multisystem trauma has not yet been reached. Advocates of early spine fixation cite multiple intuitive advantages when managing severely injured patients with unstable spine fractures. Prolonged bed rest and the inability of adequate positioning and mobilization of polytrauma patients have been associated with severe posttraumatic complications. These include the development of pressure sores, pulmonary complications, and thromboembolic events. Multiply injured patients are at additional increased risk of sustaining such adverse events secondary to their profound immunological dysfunction, as outlined above [1, 2]. Polytrauma patients require unrestricted options of mobilization and positioning in the ICU, including the upright seated position for treatment of head injuries and prone positioning for respiratory therapy of pulmonary complications, such as the acute respiratory distress syndrome (ARDS) . Last but not least, any unfixated thoracolumbar fracture may contribute to the "antigenic load" of trauma by increasing stress and pain, which will add up to the overall trauma burden to the organism and turn the physiological "host defense response" into a pathological "host defense failure disease" [1, 2]. This rationale provides a strong argument for the early clearance of bed rest and log-roll precautions in multiply injured patients and forms the basis of a "spine damage control" concept in severely injured patients [9, 16, 17].
We hypothesize that the concept of "spine damage control" will provide a safe and effective treatment modality for unstable thoracolumbar fractures in multiply injured patients, associated with less complications and improved outcomes compared to conventional treatment strategies. We define "spine damage control" as a staged procedure of immediate posterior fracture reduction and instrumentation within 24 hours ("day 1 surgery") [9, 17], followed by scheduled 360° completion fusion during a physiological "time-window of opportunity" (> 3 days after trauma), if an adjunctive anterior decompression and fusion is indicated for neurological or biomechanical reasons. This concept differs from the more common elective strategy of a staged spine fixation by initial posterior fixation and delayed anterior completion by its timeliness (posterior fixation within 24 h) and expanded applicability to all unstable thoracolumbar fractures, including pure anterior column burst fractures (AO/OTA type A3).
Based on the rationale that both concepts of delayed fixation and primary "early total care" spinal fusion are considered harmful and associated with adverse outcome (Figure 2), we propose to test the concept of "spine damage control" (Figure 1F) as a potentially safe and efficient modality of spine fixation in multiply injured patients with unstable thoracolumbar fractures.
Immediate definitive (anterior and/or posterior) fracture fixation within 24 hours of admission
Delayed definitive (anterior and/or posterior) fracture fixation at > 3 days after admission;
"Spine damage control" procedure by posterior reduction and instrumentation within 24 hours of admission, with a staged anterior completion fusion at > 3 days, if indicated.
For selected patients, the posterior "spine damage control" fixation may be considered the definitive treatment, e.g. in case of a pure osseous flexion/distraction type injury ("Chance" fracture, AO/OTA type B2.1). All other patients may benefit from an adjunctive 2nd intervention for anterior 360° completion fusion, as determined by biomechanical (anterior column stabilization) and/or neurological (anterior spinal canal decompression) indications. The 2nd procedure should be performed at > 3 days, in order to bridge the acute phase of hyperinflammation and to ensure adequate resuscitation from traumatic hemorrhage and coagulopathy, in order to reduce the intraoperative risk of bleeding from cancellous bone and epidural veins .
Performing a randomized prospective trial on this topic does not appear ethically feasible. This is based on the consideration that "spine damage control" is a safe strategy for multiply injured patients and that the allocation to a "delayed care" or "early total care" treatment arm will put the patient's safety at risk. In fact, we have implemented the "spine damage control" practice as a mandatory clinical care standard at Denver Health Medical Center in 2008. This protocol mandates the clearance from log-roll precautions in any patient with a thoracolumbar fracture within 24 hours of admission, either by clearance and mobilization of patients with stable fracture patterns, or by early posterior reduction and instrumentation on day 1. Preliminary prospective data from our institution show a significant reduction of pressure sores and pulmonary complications after implementation of this clinical care standard, suggesting that "spine damage control" is feasible and safe for the management of polytrauma patients with unstable thoracolumbar fractures (Stahel et al., unpublished observations).
Age ≥ 18 years, Injury Severity Score (ISS) > 15 points, presence of unstable thoracolumbar fracture (AO/OTA location 52- or 53-) with or without spinal cord injury (ASIA scores A-E).
Age < 18 years, stable thoracolumbar fracture amenable to non-operative treatment, patients "in extremis" with an unjustifiable risk of a severe complication or death related to a spine surgical procedure performed on day 1.
Primary outcome parameter
Length of ventilator-free days/ICU days.
Secondary outcome parameters
Mortality; rate of complications, including ARDS, MOF, thromboembolic events, pressure sores, infections; long-term clinical outcome. Patients will be followed clinically for up to 1 year after trauma and assessed for radiographic outcome (fusion, maintenance of fixation), neurological impairment (ASIA score), and functional outcome (Oswestry disability index, spine VAS score). The hypothesis may be confirmed by demonstrating a lower incidence of mortality and complications, and an improved long-term outcome in the "spine damage control" group, compared to the two conventional study groups.
In summary, there is currently no consensus on the "ideal" timing and modality of spine fracture fixation in multiply injured patients. Delaying surgical fixation of unstable spine fractures in multisystem trauma has been associated with an increased risk of severe complications attributed to restrictions in mobilization by maintaining prolonged log-roll precautions. On the other hand, early spine fixation within the first 48 hours after trauma ("early total care") has been associated with a significantly increased mortality , which is likely due to exacerbation of the "lethal triad" due to increased blood loss in hypothermic and coagulopathic trauma patients [5, 9, 25]. Based on these insights, the new concept of "spine damage control" should be advocated as a safe staged procedure of early posterior reduction and instrumentation, followed by a scheduled anterior completion during the physiological "time-window of opportunity". Although this concept appears supported by common sense from a patient safety perspective, a scientific proof of concept is currently still lacking. The safety and feasibility of the "spine damage control" strategy will have to be validated in a well-designed, prospective multicenter trial on a large cohort of multiply injured patients. The long-term dissemination and implementation of "spine damage control" will likely lead to a significant reduction of posttraumatic morbidity and mortality in these critically ill patients.
- Keel M, Trentz O: Pathophysiology of polytrauma. Injury. 2005, 36 (6): 691-709. 10.1016/j.injury.2004.12.037.View ArticlePubMedGoogle Scholar
- Stahel PF, Smith WR, Moore EE: Role of biological modifiers regulating the immune response after trauma. Injury. 2007, 38 (12): 1409-1422. 10.1016/j.injury.2007.09.023.View ArticlePubMedGoogle Scholar
- MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M: Early coagulopathy predicts mortality in trauma. J Trauma. 2003, 55 (1): 39-44. 10.1097/01.TA.0000075338.21177.EF.View ArticlePubMedGoogle Scholar
- Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, Simanski C, Neugebauer E, Bouillon B: Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury. 2007, 38: 298-304. 10.1016/j.injury.2006.10.003.View ArticlePubMedGoogle Scholar
- Brohi K, Singh J, Heron M, Coats T: Acute traumatic coagulopathy. J Trauma. 2003, 54 (6): 1127-1130. 10.1097/01.TA.0000069184.82147.06.View ArticlePubMedGoogle Scholar
- Schreiber MA, Perkins J, Kiraly L, Underwood S, Wade C, Holcomb JB: Early predictors of massive transfusion in combat casualties. J Am Coll Surg. 2007, 205 (4): 541-545. 10.1016/j.jamcollsurg.2007.05.007.View ArticlePubMedGoogle Scholar
- Rotondo MF, Schwab CW, McGonigal MD, Phillips GR, Fruchterman TM, Kauder DR, Latenser BA, Angood PA: 'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury. J Trauma. 1993, 35 (3): 375-382. 10.1097/00005373-199309000-00008. discussion 382–373.View ArticlePubMedGoogle Scholar
- Rotondo MF, Zonies DH: The damage control sequence and underlying logic. Surg Clin North Am. 1997, 77 (4): 761-777. 10.1016/S0039-6109(05)70582-X.View ArticlePubMedGoogle Scholar
- Stahel PF, Heyde CE, Ertel W: Current concepts of polytrauma management. Eur J Trauma. 2005, 31: 200-211. 10.1007/s00068-005-2028-6.View ArticleGoogle Scholar
- Gebhard F, Huber-Lang M: Polytrauma – pathophysiology and management principles. Langenbecks Arch Surg. 2008, 393: 825-831. 10.1007/s00423-008-0334-2.View ArticlePubMedGoogle Scholar
- Pape HC: Effects of changing strategies of fracture fixation on immunologic changes and systemic complications after mutliple trauma: damage control orthopedic surgery. J Orthop Res. 2008, 26: 1478-1484. 10.1002/jor.20697.View ArticlePubMedGoogle Scholar
- Croce MA, Bee TK, Pritchard E, Miller PR, Fabian TC: Does optimal timing for spine fracture fixation exist?. Ann Surg. 2001, 233: 851-858. 10.1097/00000658-200106000-00016.View ArticlePubMedPubMed CentralGoogle Scholar
- Cengiz SL, Kalkan E, Bayir A, Ilik K, Basefer A: Timing of thoracolumbar spine stabilization in trauma patients – impact on neurological outcome and clinical course: a real prospective randomized controlled study. Arch Orthop Trauma Surg. 2008, 128: 959-966. 10.1007/s00402-007-0518-1.View ArticlePubMedGoogle Scholar
- Rutges JP, Oner FC, Leenen LP: Timing of thoracic and lumbar fracture fixation in spinal injuries: a systematic review of neurological and clinical outcome. Eur Spine J. 2007, 16: 579-587. 10.1007/s00586-006-0224-7.View ArticlePubMedGoogle Scholar
- Bream-Rouwenhorst HR, Beltz EA, Ross MB, Moores KG: Recent developments in the management of acute respiratory distress syndrome in adults. Am J Health Syst Pharm. 2008, 65 (1): 29-36. 10.2146/ajhp060530.View ArticlePubMedGoogle Scholar
- Kossmann T, Trease L, Freedman I, Malham G: Damage control surgery for spine trauma. Injury. 2004, 35: 661-670. 10.1016/j.injury.2004.03.005.View ArticlePubMedGoogle Scholar
- Heyde CE, Ertel W, Kayser R: Management of spine injuries in polytraumatized patients. Orthopade. 2005, 34: 889-905. 10.1007/s00132-005-0847-0.View ArticlePubMedGoogle Scholar
- Bone LB, Johnson KD, Weigelt J, Scheinberg R: Early versus delayed stabilization of femoral fractures. A prospective randomized study. J Bone Joint Surg Am. 1989, 71 (3): 336-340.PubMedGoogle Scholar
- Scalea TM, Boswell SA, Scott JD, Mitchell KA, Kramer ME, Pollak AN: External fixation as a bridge to intramedullary nailing for patients with multiple injuries and with femur fractures: damage control orthopedics. J Trauma. 2000, 48 (4): 613-621. 10.1097/00005373-200004000-00006.View ArticlePubMedGoogle Scholar
- Pape HC, Grimme K, Van Griensven M, Sott AH, Giannoudis P, Morley J, Roise O, Ellingsen E, Hildebrand F, Wiese B, Krettek C, EPOFF Study Group: Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF study group. J Trauma. 2003, 55: 7-13. 10.1097/01.TA.0000075787.69695.4E.View ArticlePubMedGoogle Scholar
- Pape HC, Rixen D, Morley J, Husebye EE, Mueller M, Dumont C, Gruner A, Oestern HJ, Bayeff-Filoff M, Garving C, Pardini D, van Griensven M, Krettek C, Giannoudis P, EPOFF Study Group: Impact of the method of initial stabilization for femoral shaft fractures in patients with multiple injuries at risk for complications (borderline patients). Ann Surg. 2007, 246: 491-499. 10.1097/SLA.0b013e3181485750.View ArticlePubMedPubMed CentralGoogle Scholar
- Morshed S, Miclau T, Bembom O, Cohen M, Knudson MM, Colford J, J M: Delayed internal fixation of femoral shaft fracture reduces mortality among patients with multisystem trauma. J Bone Joint Surg (Am). 2009, 91: 3-13. 10.2106/JBJS.H.00338.View ArticleGoogle Scholar
- Gray AC, White TO, Clutton E, Christie J, Hawes BD, Robinson CM: The stress response bilateral femoral fractures: a comparison of primary intramedullary nailing and external fixation. J Orthop Trauma. 2009, 23: 90-99. 10.1097/BOT.0b013e31819194c6.View ArticlePubMedGoogle Scholar
- Haschtmann D, Stahel PF, Heyde CE: Management of a multiple trauma patient with extensive instability of the lumbar spine as a result of a bilateral facet dislocation and multiple complete vertebral burst fractures. J Trauma. 2009, 66 (3): 922-30.View ArticlePubMedGoogle Scholar
- Stahel PF, Moore EE, Schreier SL, Flierl MA, Kashuk JL: Transfusion strategies in postinjury coagulopathy. Curr Opin Anaesthesiol. 2009, 22 (2): 289-28.View ArticlePubMedGoogle Scholar
- Spahn DR, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Gordini G, Stahel PF, Hunt BJ, Komadina R, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Rossaint R, Task Force for Advanced Bleeding Care in Trauma: Management of bleeding following major trauma: a European guideline. Crit Care. 2007, 11 (1): R17-10.1186/cc5686.View ArticlePubMedPubMed CentralGoogle Scholar
- Kerwin AJ, Frykberg ER, Schinco MA, Griffen MM, Arce CA, Nguyen TQ, Tepas JJ: The effect of early surgical treatment of traumatic spine injuries on patient mortality. J Trauma. 2007, 63 (6): 1308-1313. 10.1097/TA.0b013e31815b8361.View ArticlePubMedGoogle Scholar
- Knop C, Blauth M, Buhren V, Hax PM, Kinzl L, Mutschler W, Pommer A, Ulrich C, Wagner S, Weckbach A: Operative treatment of thoracolumbar fractures. Part II: Operation and radiology [German]. Unfallchirurg. 2000, 103: 1032-1047. 10.1007/s001130050667.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.