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Table 1 Summary of Randomized LMWH Trauma Studies which Report Bleeding Complications

From: Complications related to deep venous thrombosis prophylaxis in trauma: a systematic review of the literature

Study Design Type of LMWH No. Patients Non-Fatal Bleeding Fatal Bleeding
Geerts et al. 1996[10] Randomized     
  UH 5,000 U SC BID vs. LMWH 30 mg SC BID Enoxaparin 171* 5 (2.9%) 0
  Multi-system trauma & ISS ≥ 9     
Knudson et al. 1996[20] Randomized     
  LMWH 30 mg SC BID vs. SCD or AVI bilaterally Enoxaparin 120 6 (5%) 0
  Multi-system trauma & AIS ≥ 3 with ISS > 10     
Ginzburg et al. 2003[19] Randomized     
  LMWH 30 mg BID vs. IPC bilaterally Enoxaparin 218 13 (6%) 0
  Multi-system trauma & ISS ≥ 9     
  Multi-system Trauma Bleeding Risk 24/509 (4.7%) 0%
Green et al. 1990[17] Randomized     
  UH 5,000 U SC TID vs. LMWH 3500 U SC QD Logiparin 20 0 0
  Spinal cord trauma & complete motor paraylsis     
Spinal Cord Injury Thromboprophylaxis Investigators 2003[18] Randomized     
  UH 5,000 U SC TID + IPC vs. LMWH 30 mg SC BID Enoxaparin 230 6 (2.6%) 0
  Spinal cord trauma     
Kurtoglu et al. 2004[13] Randomized     
  LMWH 40 mg QD vs. IPC bilaterally Enoxaparin 60 2 (3.3%) 0
  Head and Spinal Trauma     
  Spinal Cord Trauma Bleeding Risk 8/310 (2.6%) 0%
  Combined Total Bleeding Risk 32/819 (3.9%) 0%
  1. * 344 patients randomized and assessed for bleeding whereas only 265 patients had venograms adequate for DVT analysis ISS, Injury Severity Score; SCD, Sequential Compression Device; IPC, Intermittent Pneumatic Compression
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Journal of Trauma Management & Outcomes

ISSN: 1752-2897

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